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Check Carefully (1)pentobarbital will reduce the level or result of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.Contraindicated (one)pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can cut down panobinostat degrees